Indications of Dexalax Capsule Treatment of Erosive Esophagitis: Dexlansoprazole is indicated for the treatment of all types of erosive esophagitis (EE) for up to 8 weeks. Maintenance of healed erosive esophagitis: Dexlansoprazole is indicated for maintenance of healing of EE and relief of heartburn for up to 6 months. Symptomatic Non-Erosive Gastroesophageal Reflux Disease: Dexlansoprazole is indicated for the treatment of heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD) for 4 weeks. Pharmacology of Dexalax Capsule Dexlansoprazole extended-release capsules are a proton pump inhibitor (PPI) that inhibits gastric acid secretion by specifically inhibiting ATPase (H+/K+) in gastric parietal cells. By acting specifically on the proton pump, Dexlansoprazole blocks the final stage of acid production. It is the Renantiomer of lansoprazole (A raxemic mixture of R and Senantiomer). Dexlansoprazole is supplied as a slow-release dual-release (DDR) formulation in a capsule for oral administration. This capsule contains a mixture of two enteric coated granules with different pH-dependent dissolution profiles. Dual delayed release formulation in dexlansoprazole, plasma concentration time profiles with two distinct peaks; The first peak occurs 1 to 2 hours after administration, followed by a second peak within 4 to 5 hours. After oral administration, the mean Cmax and AUC values of Dexlansoprazole increased in proportion to the dose. Dexlansoprazole is extensively metabolized in the liver and excreted in the urine. Dexalax Capsule Dosage Recommended Dosage for dexlansoprazole Maintenance of healed erosive esophagitis and relief of heartburn: 30 mg once daily Symptomatic non-erosive GERD: 30 mg once daily for 4 weeks Healing of erosive esophagitis: 60 mg x 1 time/day for 8 weeks Administration Dexlansoprazole can be taken regardless of food. It should be swallowed whole. Alternatively, Dexlansoprazole capsules can be used as follows: Open capsules Sprinkle whole seeds on a tablespoon Swallow immediately. The seeds are not chewed. If you miss a capsule at its normal time, it should be taken as soon as possible. But if it is too close to the time for the next dose, only take the prescribed dose. A double dose should not be taken. Interaction With drugs: Atazanavir, Warfarin, Tacrolimus, Clopidogrel & Methotrexate. For food and others: No data available. Contraindications Dexlansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation. Side Effects Common side effects: Diarrhea, abdominal pain, nausea, vomiting & flatulence. Pregnancy & Lactation Group B pregnancy. There are no adequate and well-controlled studies with dexlansoprazole in pregnant women. There are no adequate and well-controlled studies with Dexlansoprazole in nursing mothers. Precautions & Warnings Stomach malignancy, Clostridium difficile associated diarrhea, fractures, hypotension, and concomitant use of dexlansoprazole and methotrexate. Therapeutic Class Proton Pump Inhibitor Storage Conditions Store below 30°C temperature & in a dry place, protected from light. Keep all medicines out of reach of children. Pharmaceutical Name Delta Pharma Ltd
