2. How ATOVA^® EZ works in our body?
ATOVA^® EZ has a complementary Mechanism of Action which treats 2 sources of LDL-C. ATOVA^® EZ,

• Works in the liver to reduce the cholesterol that the body makes naturally
• In the digestive tract, it helps block the absorption of cholesterol that comes naturally from food
• Atorvastatin of ATOVA^® EZ lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver
• Ezetimibe of ATOVA^® EZ reduces blood cholesterol by inhibiting the absorption of cholesterol by the small intestine

3. What are the indications of ATOVA^® EZ?
Primary Hyperlipidemia
ATOVA^® EZ is indicated for the reduction of elevated total cholesterol (Total-C), low-density lipoprotein cholesterol (LDL-C), Apo-lipoprotein B (Apo-B), triglycerides (TG), and non-high-density lipoprotein cholesterol (non-HDL-C), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemia.
Homozygous Familial Hypercholesterolemia (HoFH)
ATOVA EZ is indicated for the reduction of elevated Total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable.

4. What are the dosage & administration of ATOVA^® EZ?
The dosage ranges of ATOVA^® EZ is 10/10 mg to 10/80 mg daily. The recommended starting dose of ATOVA^® EZ is 10/10 mg or 10/20 mg daily. ATOVA^® EZ can be administered as a single dose at any time of the day, with or without food. The recommended starting dose for patients who require a larger reduction in LDL-C (greater than 55%) is 10/40 mg daily. After initiation and/or upon titration of ATOVA^® EZ, lipid levels should be analyzed within 2 or more weeks and dosage adjusted accordingly.
Patients with Homozygous Familial Hypercholesterolemia
The dosage of ATOVA^® EZ in patients with homozygous familial hypercholesterolemia is 10/40 mg or 10/80 mg daily. ATOVA^® EZ should be used as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) in these patients or if such treatments are unavailable.
Patients with Hepatic Impairment
ATOVA^® EZ is contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levels.
Patients with Renal Impairment
A history of renal impairment may be a risk factor for statin-associated myopathy. These patients need closer monitoring for skeletal muscle effects. In patients with renal impairment, no dosage adjustment of ATOVA^® EZ is necessary.

5. What are the contraindications of ATOVA^® EZ?
Active liver disease or unexplained persistent elevations of hepatic transaminase levels. Hypersensitivity to any component of ATOVA^® EZ.

6. What are the adverse effects of ATOVA^® EZ?
Common side effects are rhabdomyolysis, myopathy, liver enzyme abnormalities, myalgia, abdominal pain, increased hepatic enzymes.

7. What would be the storage condition of ATOVA^® EZ?
Do not store above 30^°C. Do not refrigerate or freeze. Keep in a dry place. Protect from light & keep out of the reach of children.